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Bisphenol A (BPA) and Increased Risk for Diabetes and Heart Disease
Tuesday, 30 September 2008 16:02
In the first large-scale population-based evaluation of the association between Bisphenol A (BPA) and health outcomes, Iain Lang and colleagues1 discovered that men and women with above average levels of urinary BPA were at a 39% increased risk for diabetes and at a 28 to 40% increased risk for cardiovascular disease as indicted by diagnosed angina, coronary heart disease, or history of a heart attack.

BPA is a widely used high production chemical used in plastic and epoxy resins and is often found in baby bottles, plastic and metal food containers, and in dental sealants. Research has shown that at any given time, nine out of 10 Americans have detectable levels of BPA circulating throughout their bodies. Findings were based on data from the 2003-2004 National Health and Nutrition Examination Survey. For the study researchers measured urinary BPA in 1455 adults between the ages of 18 and 74. Results were found to persist after adjusting for age, sex, race/ethnicity, education, income, body mass index, and waist circumference.

References

1. Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 2008;300:1303-10.

2. Daston GP. CERHR bisphenol A: review and commentaries. Birth Defects Res.B Dev.Reprod.Toxicol. 2008;83:151.

3. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ.Health Perspect. 2008;116:39-44.

Read more about BPA
Read more about avoiding BPA by avoiding bottled water
Read more about avoiding BPA by using safer plastics
BPA free plastics, baby bottles, water bottles and more are available in the Living the Science Clean & Green Marketplace and can also be purchased through several online retailers including Amazon.com and Drugstore.com.

BPA Free items available through the Amazon.com website:

BPA Free Plastic Storage Containers

Glass Storage Containers

BPA Free Water Bottles

BPA Free Baby Bottles

BPA Free Baby Products

BPA Free Toys

 


Research References

1. CERHR (Center for the Evaluation of Risks to Human Reproduction). NTP-CERHR Monograph on the Potential Human and Developmental Effects of Bisphenol A . National Toxicology Program,U.S.Department of Health and Human Services. 2008.

2. Kim JC, Shin HC, Cha SW, Koh WS, Chung MK, Han SS. Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy. Life Sci. 2001;69:2611-25.

3. Tyl RW, Myers CB, Marr MC, Sloan CS, Castillo NP, Veselica MM et al.Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice. Toxicol.Sci. 2008;104:362-84.

4. Takahashi O, Oishi S. Testicular toxicity of dietary 2,2-bis(4-hydroxyphenyl)propane (bisphenol A) in F344 rats. Arch.Toxicol. 2001;75:42-51.

5. Yamasaki K, Sawaki M, Noda S, Imatanaka N, Takatsuki M. Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Arch.Toxicol. 2002;76:65-74.

6. Ho SM, Tang WY, Belmonte dF, Prins GS. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res. 2006;66:5624-32.

7. Murray TJ, Maffini MV, Ucci AA, Sonnenschein C, Soto AM. Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Reprod.Toxicol. 2007;23:383-90.

8. Ryan BC, Vandenbergh JG. Developmental exposure to environmental estrogens alters anxiety and spatial memory in female mice. Horm.Behav. 2006;50:85-93.

9. Tyl RW, Myers CB, Marr MC, Thomas BF, Keimowitz AR, Brine DR et al. Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. Toxicol.Sci. 2002;68:121-46.

10. Timms BG, Howdeshell KL, Barton L, Bradley S, Richter CA, vom Saal FS. Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. Proc.Natl.Acad.Sci.U.S.A 2005;102:7014-19.

 

 
 
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