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| Mercury |
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Substance and Sources
Health Effects Avoiding Mercury: Living the Science Recommendations and Resources Do More Research References Substance and Sources: What is Mercury? Mercury (Hg) is a heavy metal and is liquid at or near room temperature. Mercury is mostly obtained from the mineral cinnabar and is deposited worldwide. Although Mercury is harmless in insoluable forms (e.g. mercuric sulfide) it poisonous in its soluble forms (e.g. mercuric chloride, methylmercury). Common Sources: Although most modern uses of mercury tend to be industrial (e.g used to make laboratory equipment and some types of telescopes), mercury is a very common ingredient in mascara and is present in nearly all dental amalgams. Humans are often exposed to mercury when they consume fish that have stores of mercury in their bodies. Larger fish like shark, swordfish, and tilefish tend to store larger amounts of mercury in their tissues. Health Effects: When ingested, approximately 95% of mercury is absorbed into the body. The half-life for mercury in the body is approximately 70 days. It is slowly excreted from the body, mainly in feces. Given the slow clearance of mercury from the body, chronic exposure (exposure on a regular basis) can lead to a build up of mercury in body tissues. Moderate to acute mercury exposure has been linked to increases in heart rate and blood pressure, abdominal pain, nausea and vomiting, frequent nosebleeds, impaired thyroid functioning, problems with menstruation, infertility, birth defects, neurologic abnormalities such as mental retardation and autism, and a number of other series health effects. Mild to acute exposure has been shown to increase the risk of many other conditions including perhaps most notably, neurologic abnormalities such as problems with attention and memory and mild to severe changes in behavior and personality. Women and men exposed to mercury at mild to moderate levels have been shown to have decreased fertility and be more likely to have offspring die during pregnancy or born with birth defects. Living the Science Recommendations and Resources: Mercury Books With More Information About Mercury in Fish Books With More Information About Heavy Metals in our Food Books With More Information About Toxins in Cosmetics Tuna with Certified Low Levels of Mercury Several organizations including the Sierra Club Research References 1. Abdel-Hamid,H.A., Fahmy,F.C. & Sharaf,I.A. Influence of free radicals on cardiovascular risk due to occupational exposure to mercury. J. Egypt. Public Health Assoc. 76, 53-69 (2001). 2. Abdelouahab,N. et al. Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada). Environ. Res. 107, 380-392 (2008). 3. Al Saleh,I. et al. Cadmium and mercury levels in Saudi women and its possible relationship with hypertension. Biol. Trace Elem. Res. 112, 13-29 (2006). 4. Al Saleh,I. et al. Exposure to heavy metals (lead, cadmium and mercury) and its effect on the outcome of in-vitro fertilization treatment. Int. J. Hyg. Environ. Health 211, 560-579 (2008). 5. Barregard,L., Lindstedt,G., Schutz,A. & Sallsten,G. Endocrine function in mercury exposed chloralkali workers. Occup. Environ. Med. 51, 536-540 (1994). 6. Carmignani,M. et al. Renal mechanisms in the cardiovascular effects of chronic exposure to inorganic mercury in rats. Br. J. Ind. Med. 49, 226-232 (1992). 7. Cheuk,D.K. & Wong,V. Attention-deficit hyperactivity disorder and blood mercury level: a case-control study in chinese children. Neuropediatrics 37, 234-240 (2006). 8. Choy,C.M. et al. Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. BJOG. 109, 1121-1125 (2002). 9. Christoforidis,A., Stamatis,N., Schmieder,K. & Tsachalidis,E. Organochlorine and mercury contamination in fish tissues from the River Nestos, Greece. Chemosphere 70, 694-702 (2008). 10. Clarkson,T.W. & Magos,L. The toxicology of mercury and its chemical compounds. Crit Rev. Toxicol. 36, 609-662 (2006). 11. Dorea,J.G., de Souza,J.R., Rodrigues,P., Ferrari,I. & Barbosa,A.C. Hair mercury (signature of fish consumption) and cardiovascular risk in Munduruku and Kayabi Indians of Amazonia. Environ. Res. 97, 209-219 (2005). 12. Edlich,R.F., Cross,C.L., Wack,C.A., Long,W.B., III & Newkirk,A.T. The food and drug administration agrees to classify mercury fillings. J. Environ. Pathol. Toxicol. Oncol. 27, 303-305 (2008). 13. Ellingsen,D.G. et al. Effects of low mercury vapour exposure on the thyroid function in chloralkali workers. J. Appl. Toxicol. 20, 483-489 (2000). 14. Erfurth,E.M., Schutz,A., Nilsson,A., Barregard,L. & Skerfving,S. Normal pituitary hormone response to thyrotrophin and gonadotrophin releasing hormones in subjects exposed to elemental mercury vapour. Br. J. Ind. Med. 47, 639-644 (1990). 15. Fillion,M. et al. A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon. Environ. Health 5, 29 (2006). 16. Fischer,C., Fredriksson,A. & Eriksson,P. Neonatal co-exposure to low doses of an ortho-PCB (PCB 153) and methyl mercury exacerbate defective developmental neurobehavior in mice. Toxicology 244, 157-165 (2008). 17. Fischer,C., Fredriksson,A. & Eriksson,P. Coexposure of neonatal mice to a flame retardant PBDE 99 (2,2',4,4',5-pentabromodiphenyl ether) and methyl mercury enhances developmental neurotoxic defects. Toxicol. Sci. 101, 275-285 (2008). 18. Fu,W.Z. [Effects of mercury exposure on reproduction in female workers]. Zhonghua Yu Fang Yi. Xue. Za Zhi. 27, 347-349 (1993). 19. Geier,D.A., King,P.G., Sykes,L.K. & Geier,M.R. A comprehensive review of mercury provoked autism. Indian J. Med. Res. 128, 383-411 (2008). 20. Ghosh,N. & Bhattacharya,S. Thyrotoxicity of the chlorides of cadmium and mercury in rabbit. Biomed. Environ. Sci. 5, 236-240 (1992). 21. Goldoni,M. et al. Methylmercury at low doses modulates the toxicity of PCB153 on PC12 neuronal cell line in asynchronous combination experiments. Food Chem. Toxicol. 46, 808-811 (2008). 22. Ha,M. et al. Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: A report of the children's health and environment research (CHEER). Neurotoxicology 30, 31-36 (2009). 23. Hanf,V. et al. Mercury in urine and ejaculate in husbands of barren couples. Toxicol. Lett. 88, 227-231 (1996). 24. Hinck,J.E. et al. Chemical contaminants, health indicators, and reproductive biomarker responses in fish from rivers in the Southeastern United States. Sci. Total Environ. 390, 538-557 (2008). 25. Houston,M.C. The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. Altern. Ther. Health Med. 13, S128-S133 (2007). 26. Jacobson,J.L. et al. Beneficial effects of a polyunsaturated fatty acid on infant development: evidence from the inuit of arctic Quebec. J. Pediatr. 152, 356-364 (2008). 27. Kobal,A.B. et al. The impact of long-term past exposure to elemental mercury on antioxidative capacity and lipid peroxidation in mercury miners. J. Trace Elem. Med. Biol. 17, 261-274 (2004). 28. Kokayi,K., Altman,C.H., Callely,R.W. & Harrison,A. Findings of and treatment for high levels of mercury and lead toxicity in ground zero rescue and recovery workers and lower Manhattan residents. Explore. (NY) 2, 400-407 (2006). 29. Kuntz,W.D., Pitkin,R.M., Bostrom,A.W. & Hughes,M.S. Maternal and cord blood background mercury levels: a longitudinal surveillance. Am. J. Obstet. Gynecol. 143, 440-443 (1982). 30. Langworth,S. & Stromberg,R. A case of high mercury exposure from dental amalgam. Eur. J. Oral Sci. 104, 320-321 (1996). 31. Madeddu,A. & Sciacca,S. [Biological tracking on the presence of Hg, PCB and HCG in milk and hair of women resident in a region with high incidence of children born with malformation (Augusta)]. Ann. Ig 20, 59-64 (2008). 32. Padhi,B.K. et al. Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides. Toxicol. Lett. 176, 93-103 (2008). 33. Padula,D.J., Daughtry,B.J. & Nowak,B.F. Dioxins, PCBs, metals, metalloids, pesticides and antimicrobial residues in wild and farmed Australian southern bluefin tuna (Thunnus maccoyii). Chemosphere 72, 34-44 (2008). 34. Palkovicova,L., Ursinyova,M., Masanova,V., Yu,Z. & Hertz-Picciotto,I. Maternal amalgam dental fillings as the source of mercury exposure in developing fetus and newborn. J. Expo. Sci. Environ. Epidemiol. 18, 326-331 (2008). 35. Pan,J., Song,H. & Pan,X.C. [Reproductive effects of occupational exposure to mercury on female workers in China: a meta-analysis]. Zhonghua Liu Xing. Bing. Xue. Za Zhi. 28, 1215-1218 (2007). 36. Pelletier,G. et al. Contribution of methylmercury, polychlorinated biphenyls and organochlorine pesticides to the toxicity of a contaminant mixture based on Canadian Arctic population blood profiles. Toxicol. Lett. (2008). 37. Piedrafita,B., Erceg,S., Cauli,O. & Felipo,V. Developmental exposure to polychlorinated biphenyls or methylmercury, but not to its combination, impairs the glutamate-nitric oxide-cyclic GMP pathway and learning in 3-month-old rats. Neuroscience 154, 1408-1416 (2008). 38. Pierce,G.J. et al. Bioaccumulation of persistent organic pollutants in female common dolphins (Delphinus delphis) and harbour porpoises (Phocoena phocoena) from western European seas: geographical trends, causal factors and effects on reproduction and mortality. Environ. Pollut. 153, 401-415 (2008). 39. Rowland,A.S. et al. The effect of occupational exposure to mercury vapour on the fertility of female dental assistants. Occup. Environ. Med. 51, 28-34 (1994). 40. Schell,L.M. et al. Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p'- DDE, and other toxicants in Akwesasne Mohawk youth. Environ. Health Perspect. 116, 806-813 (2008). 41. Schuurs,A.H. Reproductive toxicity of occupational mercury. A review of the literature. J. Dent. 27, 249-256 (1999). 42. Shoemaker,P.A. & Ghaemghami,J. Protecting the public from mercury exposure: success through microexchange events. Am. J. Public Health 93, 1997-1999 (2003). 43. Siblerud,R.L. The relationship between mercury from dental amalgam and the cardiovascular system. Sci. Total Environ. 99, 23-35 (1990). 44. Sioen,I. et al. Probabilistic intake assessment of multiple compounds as a tool to quantify the nutritional-toxicological conflict related to seafood consumption. Chemosphere 71, 1056-1066 (2008). 45. Smith,A.M. Mercury poisoning and birth defects in Japan. Women Health 3, 9-12 (1978). 46. Snyder,R.D. Congenital mercury poisoning. N. Engl. J. Med. 284, 1014-1016 (1971). 47. Storelli,M.M. Potential human health risks from metals (Hg, Cd, and Pb) and polychlorinated biphenyls (PCBs) via seafood consumption: estimation of target hazard quotients (THQs) and toxic equivalents (TEQs). Food Chem. Toxicol. 46, 2782-2788 (2008). 48. Sugawara,N. et al. Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice. Arch. Toxicol. 82, 387-397 (2008). 49. Takser,L. et al. Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury. Environ. Health Perspect. 113, 1039-1045 (2005). 50. Turunen,A.W. et al. Mortality in a cohort with high fish consumption. Int. J. Epidemiol. 37, 1008-1017 (2008). 51. Valera,B., Dewailly,E. & Poirier,P. Cardiac autonomic activity and blood pressure among Nunavik Inuit adults exposed to environmental mercury: a cross-sectional study. Environ. Health 7, 29 (2008). 52. Vas,J. & Monestier,M. Immunology of mercury. Ann. N. Y. Acad. Sci. 1143, 240-267 (2008). 53. Vassallo,D.V. et al. [Acute toxic actions of mercury on the cardiovascular system]. Arq Bras. Cardiol. 67, 39-45 (1996). 54. Wang,L. [Diagnosis, treatment and prevention of pediatric mercury poisoning]. Zhongguo Dang. Dai Er. Ke. Za Zhi. 10, 573-576 (2008). 55. Weber,R.F. & de Baat,C. [Male fertility. Possibly affected by occupational exposure to mercury]. Ned. Tijdschr. Tandheelkd. 107, 495-498 (2000). 56. Yang,J.M., Chen,Q.Y. & Jiang,X.Z. Effects of metallic mercury on the perimenstrual symptoms and menstrual outcomes of exposed workers. Am. J. Ind. Med. 42, 403-409 (2002). 57. Ye,X. et al. Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings. Int. J. Hyg. Environ. Health (2008). 58. Zachi,E.C., D F V, Faria,M.A. & Taub,A. Neuropsychological dysfunction related to earlier occupational exposure to mercury vapor. Braz. J. Med. Biol. Res. 40, 425-433 (2007). |